教师

Human cytomegalovirus pathogenesis and persistence. 

Understanding the epidemiology and pathogenesis of viral hemorrhagic and encephalitic arboviruses and host-vector interactions.

My research is primarily focused on defining the role of SHIP1 in immunity, 肥胖, 干细胞生物学和癌症. This research has revealed that SHIP1 is at the nexus of signaling pathways that regulate: (1) hematopoietic and mesenchymal stem cell homeostasis, (2) terminal differentiation of myeloid cells, 急性骨髓移植排斥反应, (4) survival of T cells in the small intestine and (5) survival of hematologic cancer cells. More recently we developed SHIP1 and pan-SHIP1/2 inhibitors and showed they can expand stem cells in vivo, 逆转肥胖, eradicate certain cancers and boost tumor immunity. We are also attempting to better understand what LRBA does in immune cells. LRBA is a scaffold protein that coordinates intracellular vesicle trafficking with receptor signaling.

My group is interested to identify functional consequences of defect membrane anchor synthesis in innate immune cells. We study particularly the effect on membrane-bound versus soluble molecules that derive from monocytes. A dysregulation of the membrane-to-soluble ratio could have a direct impact on the development of conditions such as atherosclerosis through skewed macrophage differentiation and metabolic reprogramming, 脂质摄取和泡沫细胞形成. 进一步, the generation of excessive amounts of damaging reactive oxygen species may lead to metabolic exhaustion in these cells in response to infections. We are also investigating the mechanistic basics of mitochondrial dysfunction and innate immunity activation as a driver of systemic inflammation and comorbidity risk factors in 肥胖.

My laboratory is interested how the activation and potential dysregulation of the innate immune system contributes to the onset and progression of autoimmune diseases such as Systemic Lupus Erythematosus (SLE). We were initially researching if and how viral RNAs can trigger SLE-like symptoms, 有趣的是，我们发现细胞内, antiviral pathways that converge at mitochondria can be activated in SLE patients in the absence of any viral infection. This activation correlates with the high type I interferon (IFN) signature which is characteristic for individuals with SLE. We found that oxidative stress plays an important role in the dysregulation of these innate immune pathways. 因此, we have expanded our research to identify environmental factors that generate oxidative stress, which in turn leads to metabolic dysregulation and ultimately to SLE pathology. Our long-term goal is to develop refined approaches to diagnose the causes of SLE, and to stratify therapeutic treatments for SLE patients.

水痘带状疱疹发病机制.

Host antiviral responses and Herpesviruses

Translational medicine with a focus on novel therapeutics and vaccines; Lyme and tick borne diseases.

Genes and Viruses Predisposing to Autoimmunity, 遗传学, 细胞凋亡, 内源性逆转录病毒, Transaldolase

Investigate the role of Cx43 gap junctions and hemichannels in immunity

My laboratory seeks to advance our understanding of the interplay between the host immune response and metabolic status in the context of both acute and chronic viral infections (e.g.、HIV-1和SARS-CoV-2). Our efforts are aimed at informing strategies with the ultimate goal of reducing the burden of these viral infections in high-risk populations.

1. Effect of co-infection on the clinical outcome of Lyme disease and Powassan encephalitis.
2. Impact of ecological changes on geographic expansion of Powassan virus and other tick borne diseases in 推荐最近最火的赌博软件 New York.
3. Tick and tick borne diseases surveillance in 推荐最近最火的赌博软件 New York.
4. Tick determinants of Powassan virus transmission.
5. Arthropod-virus-host interface: Nidus of arbovirus transmission. 
6. The effect of mosquito salivary factors on Chikungunya and Zika virus infection and dissemination.
7. Development of tick transmission model for Heartland virus pathogenesis.
8. 传染病生态学

Virology, Countermeasure Development, Global Health Security.

My group is dedicated to understanding how the interactions between infectious organisms and the human immune system result in pathogenesis and/or durable immunity. Our work is primarily focused on viral pathogens, and leverages \"next generation\" technologies such as single cell RNA sequencing, 多参数流式细胞术, 计算建模.

Understanding plasma cell and antibody longevity with a focus on host-microbiome interactions and IgA responses that lead to protection during sepsis.

Host defense against intracellular pathogens, B cell responses, immunological memory